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わかさの秘密トップ > 成分情報 > ラクトフェリン > ラクトフェリン 参考文献

作成日 2012年09月12日
更新日 2014年05月02日

ラクトフェリン

lactoferrin

ラクトフェリンとは、鉄と結合する性質を持つ糖たんぱく質で、母乳や哺乳動物の乳に多く含まれています。
ラクトフェリンは、鉄と結び付くことで細菌の増殖を抑え、免疫機能を高めます。また、腸内に入ると悪玉菌の増殖を抑え、善玉菌を増やす働きがあるため、腸内の環境を整える効果もあります。

参考文献

・Di Mario F, Aragona G, Bò ND, Ingegnoli A, Cavestro GM, Moussa AM, Iori V, Leandro G, Pilotto A, Franzè A. 2003 “Use of lactoferrin for Helicobacter pylori eradication. Preliminary results.” J Clin Gastroenterol. 2003 May-Jun;36(5):396-8.

・Koikawa N, Nagaoka I, Yamaguchi M, Hamano H, Yamauchi K, Sawaki K. 2008 “Preventive effect of lactoferrin intake on anemia in female long distance runners.” Biosci Biotechnol Biochem. 2008 Apr;72(4):931-5.

・Ono T, Morishita S, Fujisaki C, Ohdera M, Murakoshi M, Iida N, Kato H, Miyashita K, Iigo M, Yoshida T, Sugiyama K, Nishino H. 2011 “Effects of pepsin and trypsin on the anti-adipogenic action of lactoferrin against pre-adipocytes derived from rat mesenteric fat.” Br J Nutr. 2011 Jan;105(2):200-11.

・Ono T, Murakoshi M, Suzuki N, Iida N, Ohdera M, Iigo M, Yoshida T, Sugiyama K, Nishino H. 2010 “Potent anti-obesity effect of enteric-coated lactoferrin: decrease in visceral fat accumulation in Japanese men and women with abdominal obesity after 8-week administration of enteric-coated lactoferrin tablets.” Br J Nutr. 2010 Dec;104(11):1688-95.

・Zuccotti GV, Trabattoni D, Morelli M, Borgonovo S, Schneider L, Clerici M. 2009 “Immune modulation by lactoferrin and curcumin in children with recurrent respiratory infections.” J Biol Regul Homeost Agents. 2009 Apr-Jun;23(2):119-23.

・Manzoni P, Rinaldi M, Cattani S, Pugni L, Romeo MG, Messner H, Stolfi I, Decembrino L, Laforgia N, Vagnarelli F, Memo L, Bordignon L, Saia OS, Maule M, Gallo E, Mostert M, Magnani C, Quercia M, Bollani L, Pedicino R, Renzullo L, Betta P, Mosca F, Ferrari F, Magaldi R, Stronati M, Farina D; Italian Task Force for the Study and Prevention of Neonatal Fungal Infections, Italian Society of Neonatology. 2009 “Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial.” JAMA. 2009 Oct 7;302(13):1421-8.

・Mulder AM, Connellan PA, Oliver CJ, Morris CA, Stevenson LM. 2008 “Bovine lactoferrin supplementation supports immune and antioxidant status in healthy human males.” Nutr Res. 2008 Sep;28(9):583-9.

・Bharadwaj S, Naidu AG, Betageri GV, Prasadarao NV, Naidu AS. 2009 “Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women.” Osteoporos Int. 2009 Sep;20(9):1603-11.

・Cornish J, Naot D. 2010 “Lactoferrin as an effector molecule in the skeleton.” Biometals. 2010 Jun;23(3):425-30.

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