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作成日 2012年09月11日
更新日 2014年06月17日

アスタキサンチン

astaxanthin  astaxanthine

アスタキサンチンとは、サケやイクラに含まれる強力な抗酸化力を持つ赤色の天然色素です。
栄養が届きにくい細部まで入り込むことができるため、目の奥や脳までしっかり届きます。
眼精疲労の改善効果や動脈硬化予防効果などが期待されている注目の成分です。

参考文献

・アスタキサンチンが調節機能の回復におよぼす影響、臨床医薬、21,431,2005

・アスタキサンチンの調節機能および疲れ眼に及ぼす影響―健常成人を対象とした効果確認試験―、臨床医薬、21,637,2005

・アスタキサンチンのスポーツパフォーマンスに及ぼす影響―運動選手の視機能と筋肉疲労回復に対する効果について―、臨床医薬、18, 1085, 2002

・ヘマトコッカス由来アスタキサンチンの皮膚に及ぼす影響-ヒト皮膚刺激性試験・反復塗布試験・目尻シワ取り効果-、Fragrance Journal, 12, 98, 2001

・アスタキサンチンの食品機能性11―メタボリックシンドロームに対する有効性―、FOOD Style 21, 11, 11, 1, 2007

・Nagaki Y. et al. 2006 “The supplementation effect of Astaxanthin on Accommodation and Asthenopia.” J. Clin. Ther. Med, 22(1):41-54)

・Inoue M, Tanabe H, Matsumoto A, Takagi M, Umegaki K, Amagaya S, Takahashi J. 2012 “Astaxanthin functions differently as a selective peroxisome proliferator-activated receptor γ modulator in adipocytes and macrophages.” Biochem Pharmacol.

・Jia Y, Kim JY, Jun HJ, Kim SJ, Lee JH, Hoang MH, Hwang KY, Um SJ, Chang HI, Lee SJ. 2012 “The natural carotenoid astaxanthin, a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation by rewiring the transcriptome in lipid-loaded hepatocytes.” Mol Nutr Food Res. 2012 Jun;56(6):878-88.

・Speranza L, Pesce M, Patruno A, Franceschelli S, de Lutiis MA, Grilli A, Felaco M 2012 “Astaxanthin Treatment Reduced Oxidative Induced Pro-Inflammatory Cytokines Secretion in U937: SHP-1 as a Novel Biological Target.” Mar Drugs. 2012 Apr;10(4):890-9.

・Terazawa S, Nakajima H, Shingo M, Niwano T, Imokawa G. 2012 “Astaxanthin attenuates the UVB-induced secretion of prostaglandin E(2) and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner.” Exp Dermatol. 2012 Jul;21 Suppl 1:11-7.

・Nakajima H, Fukazawa K, Wakabayashi Y, Wakamatsu K, Senda K, Imokawa G. 2012 “Abrogating effect of a xanthophyll carotenoid astaxanthin on the stem cell factor-induced stimulation of human epidermal pigmentation.” Arch Dermatol Res. 2012 May 26

・Hama S, Takahashi K, Inai Y, Shiota K, Sakamoto R, Yamada A, Tsuchiya H, Kanamura K, Yamashita E, Kogure K. 2012 “Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage.” J Pharm Sci. 2012 Aug;101(8):2909-16.

・Barros MP, Marin DP, Bolin AP, de Cássia Santos Macedo R, Campoio TR, Fineto C Jr, Guerra BA, Polotow TG, Vardaris C, Mattei R, Otton R. 2012 “Combined astaxanthin and fish oil supplementation improves glutathione-based redox balance in rat plasma and neutrophils.” Chem Biol Interact. 2012 Apr 15;197(1):58-67.

・Tominaga K, Hongo N, Karato M, Yamashita E. 2012 “Cosmetic benefits of astaxanthin on humans subjects.” Acta Biochim Pol. 2012;59(1):43-7.

・Ryu SK, King TJ, Fujioka K, Pattison J, Pashkow FJ, Tsimikas S. 2012 “Effect of an oral astaxanthin prodrug (CDX-085) on lipoprotein levels and progression of atherosclerosis in LDLR(-/-) and ApoE(-/-) mice.” Atherosclerosis. 2012 May;222(1):99-105.

・Lennikov A, Kitaichi N, Fukase R, Murata M, Noda K, Ando R, Ohguchi T, Kawakita T, Ohno S, Ishida S. 2012 “Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops.” Mol Vis. 2012;18:455-64.

・Turkez H, Geyikoglu F, Yousef MI. 2012 “Beneficial effect of astaxanthin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury in rats.” Toxicol Ind Health.

・Chan KC, Pen PJ, Yin MC. 2012 “Anticoagulatory and antiinflammatory effects of astaxanthin in diabetic rats.” J Food Sci. 2012 Feb;77(2):H76-80.

・Sun Z, Liu J, Zeng X, Huangfu J, Jiang Y, Wang M, Chen F. 2011 “Protective actions of microalgae against endogenous and exogenous advanced glycation endproducts (AGEs) in human retinal pigment epithelial cells.” Food Funct. 2011 May;2(5):251-8.

・Yang Y, Seo JM, Nguyen A, Pham TX, Park HJ, Park Y, Kim B, Bruno RS, Lee J. 2011 “Astaxanthin-rich extract from the green alga Haematococcus pluvialis lowers plasma lipid concentrations and enhances antioxidant defense in apolipoprotein E knockout mice.” J Nutr. 2011 Sep;141(9):1611-7.

・Mattei R, Polotow TG, Vardaris CV, Guerra BA, Leite JR, Otton R, Barros MP. 2011 “Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: putative anxiolytic effects?” Pharmacol Biochem Behav. 2011 Sep;99(3):349-55.

・Choi HD, Kim JH, Chang MJ, Kyu-Youn Y, Shin WG. 2011 “Effects of astaxanthin on oxidative stress in overweight and obese adults.” Phytother Res. 2011 Dec;25(12):1813-8.

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