本文へ


わかさの秘密トップ > 成分情報 > スルフォラファン > スルフォラファン参考文献

作成日 2012年09月11日
更新日 2014年05月28日

スルフォラファン

sulforaphane

スルフォラファンは、ブロッコリーをはじめとするアブラナ科の野菜に含まれる辛み成分です。
強い抗酸化作用を持ち、老化防止や美肌に対する効果を発揮するだけではなく、体内の解毒酵素を活性化させることによって、肝機能や免疫力の向上にもつながります。

参考文献

・Fahey, J. W.; Haristoy, X.; Dolan, P. M.; Kensler, T. W.; Scholtus, I.; Stephenson, K. K.; Talalay, P.; Lozniewski, A. (2002) “Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors” Proc Natl Acad Sci U S A. 2002 May 28;99(11):7610-5.

・J.W Fahey, P Talalay (1999) “Antioxidant Functions of Sulforaphane: a Potent Inducer of Phase II Detoxication Enzymes” Food and Chemical Toxicology Volume 37, Issues 9–10, September–October 1999, Pages 973–979

・Wang M, Chen S, Wang S, Sun D, Chen J, Li Y, Han W, Yang X, Gao HQ. (2012) “Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells.” Chin J Physiol. 2012 Apr 30;55(2):134-44. doi: 10.4077/CJP.2012.BAA085.

・Lee YJ, Lee SH. (2011) “Sulforaphane induces antioxidative and antiproliferative responses by generating reactive oxygen species in human bronchial epithelial BEAS-2B cells.” J Korean Med Sci. 2011 Nov;26(11):1474-82. Epub 2011 Oct 27.

・Healy ZR, Liu H, Holtzclaw WD, Talalay P. “Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.” Cancer Epidemiol Biomarkers Prev. 2011 Jul;20(7):1516-23. Epub 2011 May 20.

・Yanaka A. (2011) “Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in vitro, and demonstrates anti-inflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects.” Curr Pharm Des. 2011;17(16):1532-40.

・Gaona-Gaona L, Molina-Jijón E, Tapia E, Zazueta C, Hernández-Pando R, Calderón-Oliver M, Zarco-Márquez G, Pinzón E, Pedraza-Chaverri J. (2011) “Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats.” Toxicology. 2011 Aug 15;286(1-3):20-7. Epub 2011 May 6.

・Shirasugi I, Kamada M, Matsui T, Sakakibara Y, Liu MC, Suiko M. (2010) “Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells.” Biosci Biotechnol Biochem. 2010;74(3):579-82. Epub 2010 Mar 7.

このページのトップへ